Cervical Cancer Outcome and Tumor-Associated Macrophages: Research Evidence

Inflammation is a key factor in cancer promotion. Tumor-associated macrophages (TAMs), as part of the tumor microenvironment, are often associated with progression tumors and worse prognosis many cancers, namely on cervical cancer. This work exhaustively summarizes conclusions different studies published concerning TAMs function cancer, from vitro using cell lines to clinical perspective (histological samples-based studies). Most have led conclusion that increased density directly related severity malignant lesion. Additionally, normally polarized into an M2 phenotype, benefiting promoting progression, resulting disease outcome. The microenvironment also highly critical contributor not only influences natural history but modulates specific immune response.